vSphere Replication is compatible with versions of ESXi Server, vCenter Server, Site Recovery Manager, databases, and Web browsers.

vSphere Replication is compatible with the same versions as vCenter Server, except for ESXi: vSphere Replication requires ESXi 5.0 or greater. See:

VMware Product Interoperability Matrixes at http://partnerweb.vmware.com/comp_guide2/sim/interop_matrix.php

VMware Compatibility Guide at http://partnerweb.vmware.com/comp_guide2/search.php?testConfig=16&deviceCategory=software

Browser compatibility at vSphere Client and vSphere Web Client Software Requirements in vSphere Installation and Setup

Browser compatibility of the VAMI depends on browsers supported by VMware Studio. See https://www.vmware.com/support/developer/studio/studio25/release_notes.html