You might be able to improve the performance of the applications on a virtual machine by associating it to the CPU numbers on a single NUMA node (manual CPU affinity).


Using a vSphere Client, right-click a virtual machine and select Edit Settings.


In the Virtual Machine Properties dialog box, select the Resources tab and select Advanced CPU.


In the Scheduling Affinity panel, set CPU affinity for different NUMA nodes.


You must manually select the boxes for all processors in the NUMA node. CPU affinity is specified on a per-processor, not on a per-node, basis.