Migrations with vMotion and DRS are supported with USB device passthrough from an ESXi host to a virtual machine.

vSphere Features Available for USB Passthrough from an ESXi Host to a Virtual Machine

Feature

Supported with USB Device Passthrough

vSphere Distributed Power Management (DPM)

No

vSphere Distributed Resource Scheduler (DRS)

Yes

vSphere Fault Tolerance

No

vSphere vMotion

Yes

For details about migration with vMotion, see Configuring USB Devices for vMotion.

If a host with connected USB devices resides in a DRS cluster with DPM enabled, you must disable DPM for that host. Otherwise DPM might turn off the host with the device, which disconnects the device from the virtual machine.