You can remove the USB controller from the virtual machine if you do not want to connect to USB passthrough devices on the ESX/ESXi host.

Verify that all USB devices are removed from the virtual machine.

1

In the vSphere Client inventory, right-click the virtual machine and select Edit Settings.

2

Click the Hardware tab and select USB controller.

3

Click Remove.

4

Click OK to save your changes and close the dialog box.

The controller is no longer connected to the virtual machine, but remains available to add at a later time.