You can remove the USB controller from the virtual machine if you do not want to connect to USB passthrough devices on the ESX/ESXi host.

Verify that all USB devices are removed from the virtual machine.


In the vSphere Client inventory, right-click the virtual machine and select Edit Settings.


Click the Hardware tab and select USB controller.


Click Remove.


Click OK to save your changes and close the dialog box.

The controller is no longer connected to the virtual machine, but remains available to add at a later time.