Specific restrictions apply when you use ESX/ESXi with an iSCSI SAN.

ESX/ESXi does not support iSCSI-connected tape devices.

You cannot use virtual-machine multipathing software to perform I/O load balancing to a single physical LUN.

ESX/ESXi does not support multipathing when you combine an independent hardware adapter with either software iSCSI adapter or dependent hardware iSCSI adapter.