You must follow the guidelines if you use vSphere Replication to protect virtual machines on sites that use Storage DRS or Storage vMotion.

vSphere Replication is compatible with vSphere Storage vMotion and vSphere Storage DRS on the protected site. You can use Storage vMotion and Storage DRS to move the disk files of a virtual machine that vSphere Replication protects, with no impact on replication.

vSphere Replication is compatible with Storage vMotion and saves the state of a disk or virtual machine when the home directory of a disk or virtual machine moves. Replication of the disk or virtual machine continues normally after the move.

A full sync causes Storage DRS to trigger Storage vMotion only if you set the Storage DRS rules to be very aggressive, or if a large number of virtual machines perform a full sync at the same time. The default I/O latency threshold for Storage DRS is 15ms. By default, Storage DRS performs loading balancing operations every 8 hours. Storage DRS also waits until it has collected sufficient statistics about the I/O load before it generates Storage vMotion recommendations. Consequently, a full sync only affects Storage DRS recommendations if the full sync lasts for a long time and if, during that time, the additional I/O that the full sync generates causes the latency to exceed the I/O latency threshold.